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Breast lumpspossible breast cancerask your doctor or health professional to show you how to examine your breasts monthly)

Safety and effectiveness in pediatric patients have not been establishedLarge and repeated doses of estrogen over an extended period of time have been shown to accelerate epiphyseal closureresulting in short adult stature if treatment is initiated before the completion of physiologic puberty in normally developing childrenIn patients in whom bone growth is not completeperiodic monitoring of bone maturation and effects on epiphyseal centers is recommended.

Endometriosis may be exacerbated with administration of estrogensA few cases of malignant transformation of residual endometrial implants have been reported in women treated post-hysterectomy with estrogen alone therapyFor patients known to have residual endometriosis post-hysterectomythe addition of progestin should be considered.

Osteoporosis from menopause is a thinning of the bones that makes them weaker and easier to breakIf you use Estrace only to prevent osteoporosis from menopausetalk with your healthcare provider about whether a different treatment or medicine without estrogens might be better for youYou and your healthcare provider should talk regularly about whether you should continue with Estrace.

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